Vascular
Anna Kowalewski in SBAs and EMQs in Surgery for Medical Students, 2021
This patient is suffering from thromboangiitis obliterans (Buerger’s disease), a condition where there is recurrent inflammation and thrombosis of the arteries and veins of the hands and feet. It is strongly associated with smoking, and first- line therapy is for the patient to quit smoking completely. However, they may require opioid analgesia.
Rheumatology
Paul Bentley, Ben Lovell in Memorizing Medicine, 2019
Buerger diseaseEpi: Middle-aged, Mediterranean men; smoking, HLA-B5 (B51)PC: CVA, PVD, Raynaud
B
Anton Sebastian in A Dictionary of the History of Medicine, 2018
Buerger, Leo (1879–1943) American urologist of Viennese origin who graduated from the College of Physicians and Surgeons in 1901. He designed the Brown–Buerger cystoscope in 1909 which helped to irrigate the bladder during cystoscopy. See Buerger disease.
A very late presentation of polymyalgia rheumatica in a patient with giant cell arteritis: recurrence or casual association?
Published in Modern Rheumatology Case Reports, 2019
Helena Flórez, Sergio Prieto-González, Georgina Espígol-Frigolé, Maria C. Cid, José Hernández-Rodríguez
Other systemic vasculitis or vasculopathies typically affecting peripheral arteries, mainly those supplying the lower limbs, include thromboangiitis obliterans (TAO) (Buerger’s disease) and polyarteritis nodosa (PAN) [13, 14]. While in TAO patients, lower limbs arteries are almost constantly involved [13], symptomatic vasculitis affecting lower extremities is reported in about 6% of PAN patients [14]. In addition, both vascular inflammatory conditions have been occasionally reported involving temporal arteries [15, 16]. In TAO patients, the acute temporal artery involvement is characterised by an inflammatory and organised endoluminal thrombus and scattered inflammatory lymphocytic and histiocytic infiltrates in the adventitia and media layers, without disruption of the muscular layer or the internal elastic lamina [15]. A temporal artery biopsy revealing neutrophilic or lymphocytic inflammation (with or without fibrinoid necrosis) of the small or medium collateral vessels surrounding a preserved temporal artery has emerged as a vascular territory useful for the diagnosis of PAN and other (small-vessel) vasculitides [16].
Thromboangiitis obliterans plasma-derived exosomal miR-223-5p inhibits cell viability and promotes cell apoptosis of human vascular smooth muscle cells by targeting VCAM1
Published in Annals of Medicine, 2021
Ying Deng, Jindong Tong, Weijun Shi, Zhongyi Tian, Bo Yu, Jingdong Tang
Thromboangiitis obliterans (TAO), also called Buerger’s disease, is a non-atherosclerotic, inflammatory vascular disorder that primarily affects small- or medium-sized arteries and veins in extremities [1]. TAO is closely associated with tobacco exposure and is characterized by the presence of a highly inflammatory thrombus in the affected vessels [2]. The vascular event-free survival of TAO patients is reported to be 41% at 5 years and 24% at 10 years [3]. Although more than a century has passed since its discovery, the pathogenesis of TAO remains elusive [4].
Network pharmacology-based approach to research the effect and mechanism of Si-Miao-Yong-An decoction against thromboangiitis obliterans
Published in Annals of Medicine, 2023
Jiaxi Zou, Weiming Xu, Ziyun Li, Ping Gao, Fangyuan Zhang, Yuting Cui, Jingqing Hu
The keywords ‘Buerger’s disease’ and ‘thromboangiitis obliterans’ were used to search through the Drugbank database [13] (https://go.drugbank.com/), the genecards database [14] (https://www.genecards.org/) and OMIM database (https://omim.org/).
Related Knowledge Centers
- Claudication
- Inflammation
- Tobacco
- Vein
- Artery
- Pain
- Thrombosis
- Tobacco Smoking
- Smokeless Tobacco
- Pulse