SKIN REJUVENATION: THE ART, THE SCIENCE, AND THE PROCEDURES
Zein E. Obagi in The Art of Skin Health Restoration and Rejuvenation, 2014
SKIN REJUVENATION DEFINED e popularity of skin rejuvenation procedures has increased exponentially over the past decade as a result of increased patient interest and technological advancements. Patients are becoming better educated and more aware of different treatment options for skin rejuvenation through the Internet. However, the seemingly endless variety of claims in advertisements sponsored by product and device companies can confuse patients. is most likely arises from the dierent perceptions among professionals of the meaning of “skin rejuvenation.” To many physicians, skin rejuvenation indicates performance of a procedure. To cosmeceutical companies, it implies use of their anti-aging topical products, and to laser and device manufacturers, it implies treatment with one of their own devices.
An introduction to skin and skin disease
Ronald Marks in Roxburgh's Common Skin Diseases, 17Ed, 2003
Skin disease is very common. However ‘healthy’ we think our skin is, it is likely that we will have suffered from some degree of acne and maybe one or other of the many common skin disorders. Atopic eczema and the other forms of eczema affect some 15 per cent of the population under the age of 12, psoriasis affects 1-2 per cent, and viral warts, seborrhoeic warts and solar keratoses affect large segments of the population. It should be noted that 10-15 per cent of the general practitioner’s work is with skin disorders, and that skin disease is the second commonest cause of loss of work. Although skin disease is not uncommon at any age, it is particularly frequent in the elderly.
Skin disease and the traveller
Ronald Marks, Richard Motley in Common Skin Diseases, 2019
Travelling on a mule through the hills and valleys of Afghanistan poses different kinds of problem to the skin compared with a cruise on a liner to the Caribbean. Apart from any psychological issues that result, travelling can also cause a host of physical minor injuries and discomforts on the skin even when ‘things go right’. Sunburn and miliaria crystallina and miliaria rubra are other potential skin problems that sometimes arise from travelling in tropical and subtropical zones. Dry scaling and cracked skin can result from exposure and travelling in or through cold climates. The chosen destination of travel will also result in exposure to the skin of the local human inhabitants. Skin plays a pivotal role in the body’s heat balance by modulating sweating and blood flow to the skin. Chronic exposure results in what is incorrectly perceived as ageing on all exposed skin surfaces.
Topical skin targeting effect of penetration modifiers on hairless mouse skin, pig abdominal skin and pig ear skin
Published in Drug Delivery, 2015
Meng Yu, Fang Guo, Ying Ling, Nan Li, Fengping Tan
Objective: This study was to investigate the topical skin targeting effects and mechanism of combination penetration modifiers of 1,2-hexanediol (or 1,2-heptanediol) and 1,4-cyclohexanediol on transdermal absorption of metronidazole (MTZ) in different skin models. Methods: Six formulations were applied to pig abdominal skin and pig ear skin models, respectively, and the results were compared with the previous data on hairless mouse skin worked out by our laboratory. Four parameters (flux, Tlag, Q24 and targeting ratio) were used to evaluate permeability and targeting effect in skin. Results: The combined penetration modifiers played a general role on decreasing permeability without reducing skin retention. The most significant skin permeability decrement to MTZ was pig abdominal skin (permeability decrement was ∼20% for hairless mouse skin, 60% for pig abdominal skin and 40% for pig ear skin, respectively) while the strongest skin targeting effect appeared in hairless mouse skin (targeting ratios were 1.79 for hairless mouse skin, 1.24 for pig abdominal skin and 1.05 for pig ear skin, respectively) under the role of penetration modifiers. Conclusions: Thickness of stratum corneum (SC) was the major factor impact on skin targeting effect. Selection criteria of skin models also have been discussed in this study.
Adaptive Skin Color Detection through Iterative Illuminant Color Estimation and Conversion for Preferred Skin Color Reproduction
Published in Molecular Crystals and Liquid Crystals, 2018
A robust skin color detection method using adaptive skin color modeling on YES color space is proposed. The skin colors are classified into three skin regions according to the Y value, and each region is modeled as the skin color in ES plane. By introducing an iterative estimation method of the illuminant color, we effectively remove the pseudo-skin colors that have been erroneously detected in skin color using the standard deviation of E-histogram. We also improve the skin color detection rate using a post-processing expansion mask that can include highlight and shadow pixels near the skin region as the skin color region.
Lipidomic analysis of epidermal lipids: a tool to predict progression of inflammatory skin disease in humans
Published in Expert Review of Proteomics, 2016
Shan Li, Gitali Ganguli-Indra, Arup K. Indra
ABSTRACT Introduction: Lipidomics is the large-scale profiling and characterization of lipid species in a biological system using mass spectrometry. The skin barrier is mainly comprised of corneocytes and a lipid-enriched extracellular matrix. The major skin lipids are ceramides, cholesterol and free fatty acids (FFA). Lipid compositions are altered in inflammatory skin disorders with disrupted skin barrier such as atopic dermatitis (AD). Areas covered: Here we discuss some of the recent applications of lipidomics in human skin biology and in inflammatory skin diseases such as AD, psoriasis and Netherton syndrome. We also review applications of lipidomics in human skin equivalent and in pre-clinical animal models of skin diseases to gain insight into the pathogenesis of the skin disease. Expert commentary: Skin lipidomics analysis could be a fast, reliable and noninvasive tool to characterize the skin lipid profile and to monitor the progression of inflammatory skin diseases such as AD.
Related Knowledge Centers
- Cellular Differentiation
- Integumentary System
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