Cardio-oncology case studies
Susan F. Dent in Practical Cardio-Oncology, 2019
A 35-year-old Swedish woman presented to our clinic for monitoring of her cardiac function during her cancer treatment. In 2010, while 6 months pregnant, she noticed a breast lump that was red and tender in the inner upper quadrant of the right breast. Ultrasound-guided core biopsy yielded a grade III infiltrating ductal carcinoma (IDC) that was estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2 positive by immunohistochemistry. Metastatic workup was negative. Clinically, she was diagnosed with stage IIIA right breast carcinoma. Prior to the initiation of her chemotherapy, she delivered a healthy baby. She was treated with neoadjuvant chemotherapy included two cycles of Adriamycin, radiation therapy for 5 weeks, followed by six cycles of TCH (docetaxel [T], carboplatin [C], trastuzumab [H]). After completion of her therapy, she underwent a modified radical mastectomy and right breast prosthesis implantation. Review of echocardiographic reports from her first round of chemotherapy revealed that her left ventricle was normal in size and she had mild to moderate LV systolic dysfunction with an ejection fraction of 40%–45%. The etiology of her mild LV systolic dysfunction was unclear and felt to be either pregnancy-related or preexisting. No images were available of her diagnostic studies performed at that time and the patient was not on medical therapy for LV dysfunction.
Critical appraisal of retrospective studies
O. Ajetunmobi in Making Sense of Critical Appraisal, 2021
A retrospective cohort study is designed to examine an alleged harmful relationship between a brand of silicon breast prosthesis (risk factor) and increasing reports of polyarthritis (outcome) in breast augmentation patients. In this study, 500 subjects who had breast augmentation procedures over a 5-year period were randomly selected from a plastic surgery database. Implantation of the Sellotec brand of breast prosthesis (risk factor) at the time of operation was then checked for in all subjects.
Breast Surgery
Tjun Tang, Elizabeth O'Riordan, Stewart Walsh in Cracking the Intercollegiate General Surgery FRCS Viva, 2020
According to ABS/BAPRAS guidelines17 for Oncoplastic Breast Reconstruction, breast reconstruction should be offered to all suitable patients for whom the MDT recommends mastectomy, unless there are contraindications. Patients may choose not to undergo breast reconstruction and alternatives to reconstruction are to have a flat chest or to wear a breast prosthesis.
Bilateral multicenter pseudohemangiomatous interstitial hyperplasia of the breast: a case report
Published in Case Reports in Plastic Surgery and Hand Surgery, 2023
Because PASH is a benign disease of the breast and is not considered a precancerous lesion or risk factor for cancer, most specialists recommend extensive local resection as the preferred treatment [20]. However, total mastectomy can be considered for extensive lesions that have spread throughout the breast [21]. There are few reports on one-stage prosthetic reconstruction performed after resection [4,6]. Here, we discuss a 43-year-old female patient with bilateral multicenter PASH. As requested by the patient and her family, nipple-areolar complex-sparing mastectomy and one-stage breast prosthesis reconstruction were performed. A follow-up of 18 months following surgery indicated no signs of tumor recurrence, the shape of the reconstructed breasts was excellent, and the patient was extremely satisfied.
Histopathological evaluation of the effect of hyperbaric oxygen therapy on capsule occurrence around silicone breast prosthesis: an experimental study
Published in Journal of Plastic Surgery and Hand Surgery, 2021
Serhat Yarar, Abdullah Arslan, Bilsev Ince, Mehmet Emin Cem Yildirim, Pembe Oltulu, Ilker Uyar, Mehmet Dadaci
Silicone breast prostheses are being used more commonly in breast reconstruction after breast augmentation or mastectomy. In general, capsular contracture is the underlying cause of complications such as pain, stiffening, breast asymmetry, and animation deformity that are seen in the late postoperative period because of the use of silicone breast prostheses [1]. It is a known fact that after foreign bodies are inserted into the body, capsule reaction occurs around them over time. There are many mechanisms and theories in the literature which were revealed about the process of capsule reaction. The most common theory of capsular reaction is a foreign body reaction which is a natural tissue response. Macrophages, T cells, and a variety of cytokines accumulate around a foreign body (implant) as an immune response. Then, the number of proinflammatory cells decreases, and the number of fibroblasts increases around the implant. Thus, a fibrous capsule occurs [2].
Mind, Body, and Spirit
Published in Oncology Issues, 2018
Barbara J. Wilson, Sara Owens, Chad Schaeffer
A myriad of professionals devoted to improving symptoms and side effects of cancer lease space in the Cancer Center area. For example, patients seeking nonpharmacologic interventions for symptom management can be treated by acupuncturists who apply principles of Chinese medicine. The acupuncturist is an independent practitioner who is licensed and works with patients by referral from a physician or by self-referral. The cancer program medical director provided guidance in choosing the right holistic practitioners for the cancer center to ensure that their philosophies and therapies were not in opposition to traditional medicine. A certified breast prosthesis fitter provides postmastectomy care. Women are fitted for bras, breast prostheses, swimwear, and other garments in a private setting with personal attention from this specialist. Illuminations, a salon and boutique, offers a variety of solutions to one of the most distressing side effects of cancer treatment—hair loss—including wigs, hats, scarves, and turbans. Patients who are interested in cryotherapy (Cold Caps) to prevent hair loss have the option of bringing the necessary supplies in and enlisting family and friends to assist with the process. A staff member with firsthand experience using cryotherapy for hair loss is available for advice and to assist patients in determining whether this option is right for them.
Related Knowledge Centers
- Breast
- Breast Reconstruction
- Lumpectomy
- Mastectomy
- Areola
- Breast Cancer
- Nipple
- Silicone
- Nipple Prosthesis
- Quadrantectomy